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1996-03-30
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Document 0966
DOCN M9650966
TI DIPLOMO: the tool for a new type of evolutionary analysis.
DT 9505
AU Weiller GF; Gibbs A; Research School of Biological Science, Australian
National; University, Camberra, Australia.
weiller@rsbscentral.anu.edu.au
SO Comput Appl Biosci. 1995 Oct;11(5):535-40. Unique Identifier : AIDSLINE
MED/96163633
AB A package of computer programs called DIPLOMO (DIstance PLOt MOnitor)
has been developed for making pairwise comparisons of different
estimates of the distances between a set of taxa by plotting them
against each other in a simple scatter plot. Taxa with similar relative
distance characteristics are thereby grouped graphically. Groupings of
different taxa may be directly identified, and the distance
characteristics of chosen groups visualised and compared using devices
to give them different colours or symbols. The program is particularly
useful for detecting and analysing subtle trends in gene sequence
evolution. This is done by comparing different components of change, for
example synonymous versus non-synonymous nucleotide changes,
transversions versus transitions and changes in different genes of the
same set of taxa, etc. The program has a wide range of other uses, for
example comparing different methods of sequence analysis, assessing
which components of genetic change correlate best with phenotypic change
or with geographical separation. This paper describes the DIPLOMO
package, and illustrates typical DIPLOMO analyses using lentivirus gene
sequence data.
DE Evaluation Studies *Evolution Genes, env Genetic Techniques
HIV-1/GENETICS HIV-2/GENETICS *Software Species Specificity
SIV/GENETICS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).